A descendant of the Senju and Uzumaki Clan, Tsunade is one of Konohagakure’s Sannin. Famed as the world’s strongest kunoichi and its greatest medical-nin. The repeated loss of her loved ones caused Tsunade to later abandon the life of a shinobi for many years. She is eventually persuaded to return to Konoha and take on the mantle of Fifth Hokage (Fifth Fire Shadow), where her skills prove invaluable to the village.